|
KMID : 0369820000300040267
|
|
Jorunal of Korean Pharmaceutical Sciences
2000 Volume.30 No. 4 p.267 ~ p.271
|
|
|
Effect of Cyclodextrins on the Solubility and Stability of Aspalatone in Aqueous Solutions
|
|
곽혜선/Gwak HS
전인구/Chun IK
|
|
|
Abstract
|
|
|
|
The effect of cyclodextrins on the solubility and stability of aspalatone (acetylsalicylic acid maltol ester, AM, CAS 147249-33-0), which has been recently found to have an antithrombotic effect, was investigated. The addition of β?cyclodextrin(β?CD),dimethyl?β?cyclodextrin(DMCD)or2?hydroxypropyl?β?cyclodextrin(HPCD) to the aqueous solution increased the solubility of AM concentration-dependently. From the phase solubility diagram, stability constants for AM?β?CD, -DMCD or -HPCD complexes were calculated to be 43.1, 78.3 and 53.0M?1. The addition of β?CD, DMCD or HPCD to AM solution retarded the degradation rate of AM in the acidic region. However, β?CD and HPCD rather acted as an accelerator of degradation in the neutral and alkaline regions. DMCD had a stabilizing effect at all pHs studied.
|
|
|
KEYWORD
|
|
|
Aspalatone, Solubility, Stability, Cyclodextrins
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|